1.Topic: Crosstalk between Inflammasome Activation and Cholesterol Metabolism
Time: 9:00 a.m., April 26, 2018
Venue: Room 608, Yifu Teaching Building
About the Speech
An important physiological regulation function can be obtained by higher mammals during the long process of evolution, which is, to cope with various environmental stresses and threats by maintaining and defending a stable internal milieu. In the regulatory process relating to the survival and development of the individuals and the entire groups, the immune system and metabolism communicate, cooperate, rely on each other, and jointly play an important regulatory role. In order to help the body to resist various pressures and threats, they cooperate and have obtained similar regulatory axes in evolution, and also shared some important molecular architectures for efficient and accurate coordination of each other. The selection or avoidance of specific metabolic pathways by immune cells is often necessary to adapt to the body’s metabolic needs or to resist stress and threats. When the selection loses balance, such as overeating or invasion of pathogenic microorganisms, it will cause relevant metabolic-immune intermodulation. Abnormalities in the mechanism result in shifts or dysregulation of the balance between the immune system and the metabolic system, leading to a series of serious diseases such as metabolic syndrome, chronic infection, and autoimmune diseases. In this pathological process, some core metabolic receptors or regulatory modules play two roles at the same time: on the one hand, to perceive excessive intake of energy substances in the body and then play a metabolic control shunt function; on the other hand, they participate in the regulation on the fate or function of immune cells, which in turn creates an imbalance in immune homeostasis.
About the Speaker
Wang Di is a professor, a doctoral supervisor, the Executive Director of the Research Center for Infection and Immunization at the Basic Medical College, and the Principle Investigator of the Immunological Metabolism Group. The group is engaged in the research on immunometabolism, investigating the effects of different metabolites and different metabolic pathways on the function of immune cells, analyzing the intermodulation mechanism of immune-metabolic homeostasis, and studying the pathological role of these regulatory mechanisms in the occurrence and development of the chronic inflammation-related metabolic syndrome. As a correspondent author and first author, he has published many research papers in academic journals such as Immunity, Nature Immunology, JEM, PNAS, and JBC. He was awarded the title of Young Scholar of Chinese Immunology in 2010 and the Young Scholar of Zhejiang University in 2011. He was awarded Outstanding Youth Fund of Zhejiang Province in 2014. He won the National Outstanding Youth Science Fund in 2015. He was sponsored by the Key Project of the National Natural Science Foundation of China in 2017. In 2018, he was selected as the Young Yangtze Scholar of the Ministry of Education, and the leading talent for scientific and technological innovations of Zhejiang Province.
2.Topic: Single Cell Mass Spectrometry in Neuroscience
About the Speaker
Professor Xiong Wei, a doctoral supervisor, was selected into the Thousand Youth Talents Program of the Organization Department of the Central Committee of the CPC. He graduated from the School of Life Sciences, Peking University in 2001, with a Bachelor of Science degree., and graduated from the School of Life Sciences, Peking University in 2006 with a PhD in Science. From 2006 to 2013, he did postdoctoral research at the National Institutes of Health (NIH) and the National Institute of Alcohol Abuse and Alcoholism (NIAAA). In March 2013, he joined the School of Life Sciences, University of Science and Technology of China. He is a key member of the Center for Excellent Innovation in Brain Science and Intelligent Technology of the Chinese Academy of Sciences. He has long been engaged in neuroscience research related to neurochemistry, pharmacology, and small molecule drug research and development, and has used a variety of advanced experimental techniques to conduct a thorough and systematic research on the molecular, cellular level, and animal behaviors. A series of important results have been achieved. His research papers were published in the international academic journals such as Nature Neuroscience, Nature Chemical Biology, Journal of Experimental Medicine, PNAS, Journal of Neuroscience, and Molecular Pharmacology etc. He also obtained a number of national-level funds.
His research interests are as follows:
(1) Regulatory mechanism of ion channel receptors and the design and synthesis of the relevant small molecule drugs
(2) Application of Mass Spectrometry in Neuroscience
(3) Neural circuits of perception, emotion, and learning memory
3.Topic: Life under the Microscope
Time: 14:00 p.m., April 26, 2018
Venue: Room 608, Yifu Teaching Building
About the Speaker
Professor Fu Chuanhai is a doctoral supervisor of the School of Life Sciences, University of Science and Technology of China, and was selected into the Thousand Youth Talents Program of the Organization Department of the Central Committee of the CPC. From 1997 to 2006, he studied at the University of Science and Technology of China. He received the bachelor’s degrees in both science and engineering, and a doctorate in cell biology. From 2006 to 2011, he did his postdoctoral research at the University of Pennsylvania. In 2011, he was appointed as the tenure track to form an independent team to implement research at the Li Ka Shing Medical School, the University of Hong Kong. After being selected into the Thousand Youth Talents Program in 2015, he resigned from the University of Hong Kong and joined the University of Science and Technology of China. Since then, he has been devoted to the study of cytoskeleton and cell division, discovering and naming several important microtubule cytoskeletal regulatory proteins. His relevant research results were published in the international biology journals such as Dev Cell, Curr Biol, Mol Biol Cell, J Biol Chem, and Cell Res etc.
His main research interests include microtubule cytoskeletal dynamics, mitochondrial dynamics, and mitosis
